| 12/09/2020 | 13:30 | Fulham FC | 0 | 3 | Arsenal FC |
| 19/09/2020 | 21:00 | Arsenal FC | 2 | 1 | West Ham United FC |
| 28/09/2020 | 21:00 | Liverpool FC | 3 | 1 | Arsenal FC |
| 04/10/2020 | 15:00 | Arsenal FC | 2 | 1 | Sheffield United FC |
| 17/10/2020 | 18:30 | Manchester City FC | 1 | 0 | Arsenal FC |
| 25/10/2020 | 21:15 | Arsenal FC | 0 | 1 | Leicester City FC |
| 01/11/2020 | 18:30 | Manchester United FC | 0 | 1 | Arsenal FC |
| 08/11/2020 | 21:15 | Arsenal FC | 0 | 3 | Aston Villa FC |
| 22/11/2020 | 18:30 | Leeds United FC | 0 | 0 | Arsenal FC |
| 29/11/2020 | 21:15 | Arsenal FC | 1 | 2 | Wolverhampton Wanderers FC |
| 06/12/2020 | 18:30 | Tottenham Hotspur FC | 2 | 0 | Arsenal FC |
| 13/12/2020 | 21:15 | Arsenal FC | 0 | 1 | Burnley FC |
| 16/12/2020 | 20:00 | Arsenal FC | 1 | 1 | Southampton FC |
| 19/12/2020 | 19:30 | Everton FC | 2 | 1 | Arsenal FC |
| 26/12/2020 | 19:30 | Arsenal FC | 3 | 1 | Chelsea FC |
| 29/12/2020 | 20:00 | Brighton & Hove Albion FC | 0 | 1 | Arsenal FC |
| 02/01/2021 | 22:00 | West Bromwich Albion FC | 0 | 4 | Arsenal FC |
| 14/01/2021 | 22:00 | Arsenal FC | 0 | 0 | Crystal Palace FC |
| 18/01/2021 | 22:00 | Arsenal FC | 3 | 0 | Newcastle United FC |
| 26/01/2021 | 22:15 | Southampton FC | 1 | 3 | Arsenal FC |
| 30/01/2021 | 19:30 | Arsenal FC | 0 | 0 | Manchester United FC |
| 02/02/2021 | 20:00 | Wolverhampton Wanderers FC | 2 | 1 | Arsenal FC |
| 06/02/2021 | 14:30 | Aston Villa FC | 1 | 0 | Arsenal FC |
| 14/02/2021 | 18:30 | Arsenal FC | 4 | 2 | Leeds United FC |
| 21/02/2021 | 18:30 | Arsenal FC | 0 | 1 | Manchester City FC |
| 28/02/2021 | 14:00 | Leicester City FC | 1 | 3 | Arsenal FC |
| 06/03/2021 | 14:30 | Burnley FC | 1 | 1 | Arsenal FC |
| 14/03/2021 | 18:30 | Arsenal FC | 2 | 1 | Tottenham Hotspur FC |
| 21/03/2021 | 17:00 | West Ham United FC | 3 | 3 | Arsenal FC |
| 03/04/2021 | 21:00 | Arsenal FC | 0 | 3 | Liverpool FC |
| 11/04/2021 | 20:00 | Sheffield United FC | 0 | 3 | Arsenal FC |
| 18/04/2021 | 14:30 | Arsenal FC | 1 | 1 | Fulham FC |
| 23/04/2021 | 21:00 | Arsenal FC | 0 | 1 | Everton FC |
| 02/05/2021 | 15:00 | Newcastle United FC | 0 | 2 | Arsenal FC |
| 09/05/2021 | 20:00 | Arsenal FC | | | West Bromwich Albion FC |
| 12/05/2021 | 21:15 | Chelsea FC | | | Arsenal FC |
| 19/05/2021 | 20:45 | Crystal Palace FC | | | Arsenal FC |
| 23/05/2021 | 17:00 | Arsenal FC | | | Brighton & Hove Albion FC |