| 12/09/2020 | 13:30 | Fulham FC | 0 | 3 | Arsenal FC |
| 19/09/2020 | 21:00 | Arsenal FC | 2 | 1 | West Ham United FC |
| 28/09/2020 | 21:00 | Liverpool FC | Arsenal FC | ||
| 04/10/2020 | 15:00 | Arsenal FC | Sheffield United FC | ||
| 18/10/2020 | 02:00 | Manchester City FC | Arsenal FC | ||
| 25/10/2020 | 02:00 | Arsenal FC | Leicester City FC | ||
| 01/11/2020 | 02:00 | Manchester United FC | Arsenal FC | ||
| 08/11/2020 | 02:00 | Arsenal FC | Aston Villa FC | ||
| 22/11/2020 | 02:00 | Leeds United FC | Arsenal FC | ||
| 29/11/2020 | 02:00 | Arsenal FC | Wolverhampton Wanderers FC | ||
| 06/12/2020 | 02:00 | Tottenham Hotspur FC | Arsenal FC | ||
| 13/12/2020 | 02:00 | Arsenal FC | Burnley FC | ||
| 16/12/2020 | 02:00 | Arsenal FC | Southampton FC | ||
| 20/12/2020 | 02:00 | Everton FC | Arsenal FC | ||
| 27/12/2020 | 02:00 | Arsenal FC | Chelsea FC | ||
| 29/12/2020 | 02:00 | Brighton & Hove Albion FC | Arsenal FC | ||
| 03/01/2021 | 02:00 | West Bromwich Albion FC | Arsenal FC | ||
| 13/01/2021 | 02:00 | Arsenal FC | Crystal Palace FC | ||
| 17/01/2021 | 02:00 | Arsenal FC | Newcastle United FC | ||
| 28/01/2021 | 02:00 | Southampton FC | Arsenal FC | ||
| 31/01/2021 | 02:00 | Arsenal FC | Manchester United FC | ||
| 03/02/2021 | 02:00 | Wolverhampton Wanderers FC | Arsenal FC | ||
| 07/02/2021 | 02:00 | Aston Villa FC | Arsenal FC | ||
| 14/02/2021 | 02:00 | Arsenal FC | Leeds United FC | ||
| 21/02/2021 | 02:00 | Arsenal FC | Manchester City FC | ||
| 28/02/2021 | 02:00 | Leicester City FC | Arsenal FC | ||
| 07/03/2021 | 02:00 | Burnley FC | Arsenal FC | ||
| 14/03/2021 | 02:00 | Arsenal FC | Tottenham Hotspur FC | ||
| 21/03/2021 | 02:00 | West Ham United FC | Arsenal FC | ||
| 04/04/2021 | 02:00 | Arsenal FC | Liverpool FC | ||
| 11/04/2021 | 02:00 | Sheffield United FC | Arsenal FC | ||
| 18/04/2021 | 02:00 | Arsenal FC | Fulham FC | ||
| 25/04/2021 | 02:00 | Arsenal FC | Everton FC | ||
| 02/05/2021 | 02:00 | Newcastle United FC | Arsenal FC | ||
| 09/05/2021 | 02:00 | Arsenal FC | West Bromwich Albion FC | ||
| 13/05/2021 | 02:00 | Chelsea FC | Arsenal FC | ||
| 16/05/2021 | 02:00 | Crystal Palace FC | Arsenal FC | ||
| 24/05/2021 | 02:00 | Arsenal FC | Brighton & Hove Albion FC |