| 12/08/2018 | 17:00 | Arsenal FC | 0 | 2 | Manchester City FC |
| 18/08/2018 | 18:30 | Chelsea FC | 3 | 2 | Arsenal FC |
| 25/08/2018 | 16:00 | Arsenal FC | 3 | 1 | West Ham United FC |
| 02/09/2018 | 14:30 | Cardiff City FC | 2 | 3 | Arsenal FC |
| 15/09/2018 | 16:00 | Newcastle United FC | 1 | 2 | Arsenal FC |
| 23/09/2018 | 17:00 | Arsenal FC | 2 | 0 | Everton FC |
| 29/09/2018 | 16:00 | Arsenal FC | 2 | 0 | Watford FC |
| 07/10/2018 | 13:00 | Fulham FC | 1 | 5 | Arsenal FC |
| 22/10/2018 | 21:00 | Arsenal FC | 3 | 1 | Leicester City FC |
| 28/10/2018 | 15:30 | Crystal Palace FC | 2 | 2 | Arsenal FC |
| 03/11/2018 | 19:30 | Arsenal FC | 1 | 1 | Liverpool FC |
| 11/11/2018 | 18:30 | Arsenal FC | 1 | 1 | Wolverhampton Wanderers FC |
| 25/11/2018 | 15:30 | AFC Bournemouth | | | Arsenal FC |
| 02/12/2018 | 16:05 | Arsenal FC | | | Tottenham Hotspur FC |
| 05/12/2018 | 22:00 | Manchester United FC | | | Arsenal FC |
| 08/12/2018 | 17:00 | Arsenal FC | | | Huddersfield Town AFC |
| 16/12/2018 | 15:30 | Southampton FC | | | Arsenal FC |
| 22/12/2018 | 14:30 | Arsenal FC | | | Burnley FC |
| 26/12/2018 | 19:15 | Brighton & Hove Albion FC | | | Arsenal FC |
| 29/12/2018 | 19:30 | Liverpool FC | | | Arsenal FC |
| 01/01/2019 | 17:00 | Arsenal FC | | | Fulham FC |
| 12/01/2019 | 14:30 | West Ham United FC | | | Arsenal FC |
| 19/01/2019 | 19:30 | Arsenal FC | | | Chelsea FC |
| 29/01/2019 | 21:45 | Arsenal FC | | | Cardiff City FC |
| 01/02/2019 | 02:00 | Manchester City FC | | | Arsenal FC |
| 08/02/2019 | 02:00 | Huddersfield Town AFC | | | Arsenal FC |
| 22/02/2019 | 02:00 | Arsenal FC | | | Southampton FC |
| 25/02/2019 | 02:00 | Arsenal FC | | | AFC Bournemouth |
| 01/03/2019 | 02:00 | Tottenham Hotspur FC | | | Arsenal FC |
| 08/03/2019 | 02:00 | Arsenal FC | | | Manchester United FC |
| 15/03/2019 | 02:00 | Wolverhampton Wanderers FC | | | Arsenal FC |
| 29/03/2019 | 02:00 | Arsenal FC | | | Newcastle United FC |
| 05/04/2019 | 02:00 | Everton FC | | | Arsenal FC |
| 12/04/2019 | 02:00 | Watford FC | | | Arsenal FC |
| 19/04/2019 | 02:00 | Arsenal FC | | | Crystal Palace FC |
| 26/04/2019 | 02:00 | Leicester City FC | | | Arsenal FC |
| 03/05/2019 | 02:00 | Arsenal FC | | | Brighton & Hove Albion FC |
| 11/05/2019 | 02:00 | Burnley FC | | | Arsenal FC |